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Karla Childers, MS, Head, Bioethics-based Science & Technology Policy for the Office of the Chief Medical Officer at Johnson & Johnson, discusses the challenges and opportunities to collaborate during crisis. The episode covers challenges to operations, supply chain, and infrastructure and creative ways to continue clinical trials. Disruptions from weather-related events, the pandemic, and war call for approaches that range from relocation to places with available hospital or medical facilities and engaging in triage absent the normal infrastructure. The discussion includes strategies to prevent future disruptions, including improved operational and regulatory flexibility.